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Protocols vary based on the condition being treated acute injuries typically involve a more intensive initial phase, followed by a maintenance dose

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More significant changes in elasticity and hyperpigmentation generally require three to six months of consistent use

10.1146/annurev.immunol.021908.132528 231 RemingtonL

Loops in the N-terminal domain are exposed on the cell surface and are binding sites for colonizing Staphylococcus aureus in atopic dermatitis lesions (Towell et al., 2021)

Published research demonstrates that Matrixyls effect is concentration-dependent and time-limited once fibroblasts have adequately responded to the matrikine signal, the collagen production response attenuates without additional stimulation from other growth factors