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(29) observed that in a mouse model, inflammation accumulation predisposed to mtDNA mutations, and in turn, mtDNA mutations facilitated inflammation accumulation, forming a specific vicious circle between the two

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Fernndez-Real et al., 2008)

Long term illness - glutathione is needed for immune function, so if you are chronically ill it can deplete your body's glutathione stores

In particular, identifications of age-related metabolic phenotypes or biomarkers that are closely correlated with overall fitness are increasingly being recognized as therapeutic targets