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Effects of two-year vitamin B12 and folic acid supplementation on depressive symptoms and quality of life in older adults with elevated homocysteine concentrations: additional results from the B-PROOF study, an RCT

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The inflammatory nature of homocysteine and the effects of decreased myelin production before the occurrence of overt demyelination create a sustained low grade inflammatory response with a relative hyperexcitation of the peripheral and central nervous system

The additive effects observed when combining NNMT inhibition with exercise indicate that the compound influences molecular pathways distinct from those activated by physical training alone

This dual action distinguishes it from compounds that work through only one mechanism

OVERALL CONCLUSIONS 5-Amino-1MQ enables precise interrogation of NNMTs role at the crossroads of NAD metabolism, one-carbon biochemistry, and adipocyte energetics