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298 Consequently, the primary goal of second-generation mTOR inhibitors is to simultaneously target both the mTORC1 and mTORC2 signaling pathways, as well as their feedback loops, which were not addressed by first-generation inhibitors

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doi:10.1016/j.bj.2019.05.007 pmid:31466708 Berndt N, Bulik S, Holzhtter H-G (2012) Kinetic modeling of the mitochondrial energy metabolism of neuronal cells: the impact of reduced -ketoglutarate dehydrogenase activities on ATP production and generation of reactive oxygen species