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British journal of pharmacology

M2 macrophages also utilize hydrolase arginase-1 to break down arginine, limiting its concentration in the local milieu and thereby depriving T cells of this vital nutrient and subsequently reducing T-cell proliferation (83)

doi: 10.1093/jn/121.7.1054 144 BuckmasterPSHollidayTABaiSCRogersQR

mTOR and KG signaling substantially mediate these processes, which manifest themselves according to the specificity of metabolism in various cell types

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Abbreviations BMP: bone morphogenetic protein CMap: Connectivity Map COPD: chronic obstructive pulmonary disease CT: computed tomography DLCO: diffusing capacity of carbon monoxide DMEM: Dulbecco's modified Eagle's medium ECM: extracellular matrix FBS: fetal bovine serum FDR: false discovery rate FEV 1 : forced expiratory volume in 1 second FVC: forced vital capacity GOLD: Global Initiative for Chronic Obstructive Lung Disease GSEA: Gene Set Enrichment Analysis Lm: mean linear intercept PBS: phosphate-buffered saline TGF: transforming growth factor Vv: volume fraction
