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For example, p53 stabilization results in down-regulation of numerous metabolic genes, and we observe that overexpression of RNR subunits alone is not sufficient to re-sensitize arrested cells to ferroptosis, perhaps due to the absence of upstream precursors that would allow RNR to operate at full capacity

When there are not enough antioxidants in our bodies, reactive free radicals can wreak havoc on our health

& Anderson, W

Another major advancement is the application of omics-based technologies such as metabolomics, gut microbiome profiling, and transcriptomics to understand the mechanisms of herbal action and host interaction

[Google Scholar] 91.Medicines & Healthcare Products Regulatory Agency Drug Safety Update

doi: 10.1046/j.1467-789X.2002.00057.x