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, 2006;Peinelt et al

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What distinguishes Melanotan 1 from Melanotan 2 and PT-141 as a research tool is its relative selectivity for MC1R over central melanocortin receptors MC3R and MC4R making it a more focused research compound for studying peripheral melanocyte biology, skin photoprotection mechanisms, and MC1R-mediated signalling without the significant central nervous system and sexual behaviour effects associated with the more promiscuous receptor profiles of other melanocortin analogues