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Docking simulations based on the complex crystal structures of GLS1 and its inhibitor CB-839 revealed that bearing thiadiazole skeletons exhibit GLS1 inhibition

Heindel and Blumberg, 2019

Notably, higher interleukin concentrations were associated with more severe behavioral symptoms ( Recent data support findings that immune cells activity in ASD subjects is compromised, with amplified inflammatory signaling and reactivity of immune cells such as B-cells, neutrophils and monocytes (Majerczyk et al., 2022)

documented that long-chain Glu analogues (such as quinoxaquine) could potently dampen the transport of cystine, while short-chain Glu analogues (such as aspartic acid or N-methyl-D-aspartate (NMDA)) exhibited no effect (Bannai 1986)

Cells were stained with CD19, 7-AAD, and anti-Annexin V-PE diluted 1:200 (BioLegend, 640908) for 20 min, RT

Loss of TBK1 is a frequent cause of frontotemporal dementia in a Belgian cohort