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The ratio of Firmicutes to Bacteroidetes is a commonly-studied change with an increase often linked to HFD consumption/obesity in mice 43,44 and humans 45,46 (for review, see John and Mullin, 2016 47 )

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The first auto-Abs to be identified in RA were shown to bind the Fc fragment of IgG, resulting in circulating ICs that deposit in the cartilage and synovium and cause immune activation and chronic inflammation [205]

Available safety data comes from animal research, limited clinical trials, and user documentation rather than the rigorous safety evaluation required for approved medications

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Membranes were washed three times in 1PBS and positive signals were developed with enhanced chemiluminescence kit (Amershan Pharmacia Biotech, Little Chalfont Buckinghamshire, England)