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Upon careful estimation, we determined that assigning 135 patients to both the study and control groups would yield more than 80% power to detect between-group differences

There is also evidence that PCSK9 induces the degradation of other LDLR-related proteins, such as very low-density lipoprotein receptor (VLDLR),apolipoprotein E receptor 2 (ApoER2), (Poirier et al., 2008), and LDLR-related protein 1 (LRP-1) (Canuel et al., 2013), as well as the unrelated fatty acid receptor CD36 (Demers et al., 2015)

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Ohara M, Ogawa K, Suda G, Kimura M, Maehara O, Shimazaki T, et al
Abarikwu SO, Iserhienrhien BO, Badejo TA
