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Similar promoter methylation events have been described in other cancers, including the extracellular regulation genes (WIF1), Dickkopf Wnt Signaling Pathway Inhibitor (DKK1-3), SFRP1, 2, 4, and 5) and intracellular regulatory genes (DACT1-3, Axin, APC)

Although many of these compounds exhibit antioxidant activity in preclinical studies, they may lack robust clinical evidence to confirm their efficacy or have not been assigned an RDI by the FDA

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Moderate levels of vitamin D may also helpcontroldisease activity
