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Long-term oral studies of acetylcysteine solution alone in rats (12 months of treatment followed by 6 months of observation) at doses up to 1,000 mg/kg/day (5.2 times the human mucolytic dose) provided no evidence of oncogenic activity

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10.1136/annrheumdis-2013-204627 14 DalalD

Mitochondrial fragmentation occurs in response to nutrient excess and cellular dysfunction escalates the prevalence of obesity, cancer, cardiovascular and neuromuscular disorders[71]

What Reclassification May Mean for Healthcare Leaders If these peptides formally move to Category 1, leaders might expect both opportunity and complexity across five major areas: 1