glutathione drug inhibitor 2′,4′-Dihydroxy-6′-methoxy-3′,5′-dimethylchalcone, a potent Nrf2/ARE pathway inhibitor, reverses resistance by decreasing synthesis and drug efflux in BEL-7402/5-FU cells Structural Biology Platform Facilitates Discovery
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The imbalance of G T and G D populations (or GTP and GDP) caused by the GEF activity-mediated exchange is restored by regulators of G protein-signaling (RGS) displaying GTPase activating protein (GAP) activity that converts G T back to G D via GTP hydrolysis
10.1371/journal.pone.0210728 75
