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After naturally cooling to room temperature, the resulting solution was filtered through a microporous filter (0.22 m) to remove insoluble impurities

doi: 10.1186/s12974-020-01948-5 187

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However, NRF2 activation directly upregulates the uncoupling protein 3 (UCP3) that uncouples respiration from oxidative phosphorylation to allow energy to be released as heat, thus decreasing superoxide formation [113]

Additionally, the decrease in pyroglutamate at M12 as compared to M0, may indicate recovery of glutathione metabolism by introduction of E-HD

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