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Nerve damage can also make it harder for men to have an erection

One of the main causes of this damage is oxidative stress

In a separate analysis in neuronal cells, overexpression of GPx-1 and other antioxidant enzymes also blocks AIF-translocation from mitochondria to the nucleus in a model of ischemia-induced apoptosis (404), suggesting that intracellular oxidants can promote AIF transmigration

Park et al., 2008b

Curr Pharm Des 2004

Its pro-angiogenic activity also carries a theoretical concern: any compound promoting new blood vessel formation could support tumor vascularization in individuals with undetected malignancies