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These molecular alterations characterize both obesity and diabetes, where chronic ER dysfunction perpetuates inflammatory signaling networks and impairs IR signal transduction through multiple intersecting pathways ( IRE1 activates JNK through TNF receptor-associated factor (TRAF2) binding, triggering inflammatory signaling cascades

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[DOI] [PMC free article] [PubMed] [Google Scholar] 187.Zarreen Simnani F, Singh D, Patel P, Choudhury A, Sinha A, Nandi A, et al

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