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It was found that the viability of the transduced cells increased significantly

commonly referred to as MST/HN) in the Fc fragment of a full-length humanized IgG1 mAb against an irrelevant antigen (hen egg lysozyme specific), they created an Ab variant with increased binding towards both human and mouse FcRn at both pH 6.0 and, to a lesser degree, pH 7.4 [115]

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Results were verified at follow-up appointments 23 weeks after initial treatment