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Common Causes Histamine Intolerance: Genetic factors Digestive issues that damage the intestinal lining Hormonal shifts during pregnancy, perimenopause, and menopause Certain medications (NSAIDS, antidepressants, antihistamines) Chronic health conditions the IBD Eating too many histamine-rich foods (pineapples, tomatoes, cheese, etc) The build up of histamines triggers an immune response and increases inflammation