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Metabolites produced by gut microbiota may influence brain neurons, and PD patients often experience gastrointestinal dysfunction

In addition, DON can inhibit cellular nucleotide production and result in cytotoxicity against AML [55]

Numerous clinical trials, primarily utilizing immunomodulatory Lactobacillus and Bifidobacterium strains, were subsequently undertaken to assess their efficacy against COVID-19 (483)

Cancers (2020) 12:2085

Hill-Burns EM, Ross OA, Wissemann WT, Soto-Ortolaza AI, Zareparsi S, Siuda J, Lynch T, Wszolek ZK, Silburn PA, Mellick GD et al (2016) Identification of genetic modifiers of age-at-onset for familial Parkinsons disease