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Rohm, M

However, many antioxidants, including so-called dietary antioxidants, have failed to demonstrate therapeutic benefits in human clinical trials (Halliwell, 2012

Effects of platelet-rich plasma against experimental ischemia/reperfusion injury in rat testis

On the other hand, activation of AMP-activated protein kinase (AMPK) reduces the expression of EAAC1 on the cell surface and suppresses its function [71]

A similar effect was obtained also using rosmarinic acid, which showed anti-inflammatory and antioxidant role in rats subjected to ischemia and reperfusion procedure [234]

Consistent with expectations, bona fide p53 targets including HDM2 and CDKN1A were among the most highly up-regulated genes in Control cells, whereas genes known to be negatively regulated by p53, such as E2F2 , were strongly down-regulated (el-Deiry et al, 1993