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This research was funded by NIH 1RO1HL127072-01A1, 1RO1HL136347-01, 1R01HL176640-01, RO1HL136347-04S1, and 1R56HL169501-01 (J.F.) Acknowledgments The authors would like to acknowledge Biorender.com for assistance in providing the platform used for creating the figures utilized in this manuscript

Second, to guide the clinician in treatment selection and the surgeon in assessing optimal approach and likely complications

Insulin should be injected into a fatty area: the abdomen (around the belly, avoiding 2 inches around navel) is common, as are the upper outer thighs or upper buttocks

Further research is needed to optimize the design and development of glycation inhibitors for therapeutic use in diseases associated with protein glycation