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doi: 10.1016/j.jss.2017.02.061
Werner syndrome (WS), which is distinguished by severe metabolic dysfunction, dyslipidemia, early atherosclerosis, and insulin resistance diabetes, is thought to most closely mimic normal aging

Asian Pacific J Cancer Prev

They suggest that DMA-induced effects may be due by an increased A anabolism (enhanced APP expression), although authors did not discard an alteration in the A degradation pathway (Zaraza et al., 2011)
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The Age Gap: A recent 2023 study highlights a critical reality of aging: our natural levels of GHK decline sharply over time
