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In addition to the acquirement of drug-resistant mutation, the development of cancer stem cells also causes CML persistence and relapse from TKI therapy 12,13,14

Additionally, the most active derivative showed an important cytotoxic effect (greater than that of resveratrol) against three human cancer cell lines: Hep-G2, SK-BR-3, and especially HT-29 (colorectal adenocarcinoma cells)

Combinatorial approaches addressing oxidative stress, neuroinflammation, and MG-induced damage may be promising

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The compound with the greater orbital gap energy tends to be energetically more unfavorable to undergo a chemical reaction and could be called bioactive [25,26]

The ABCs of Membrane Transporters in Health and Disease (SLC Series): Introduction. Molecular Aspects of Medicine 34, no