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Chen YM, Chiang WC, Lin SL, Tsai TJ

Another study demonstrated that IGF-1 administration increased overall BDNF and decreased expression of interleukin (IL)-1, TNF-, nitric oxide synthase (iNOS), and glial fibrillary acidic protein (GFAP) in the whole brain [28]

Lipoic acid also plays a key role in supporting detoxification capacity.Studies have shown that a combination of ALA and ALC helps minimize oxidative damage.Oxidative stress causes damage to DNA, RNA, proteins,mitochondrial membranes and lipids, and contributes to the functional decline of mitochondria, cells, tissues and eventually organs such as the brain (helps improve mental clarity and reduce brain fog)

Neurovascular pathways to neurodegeneration in Alzheimers disease and other disorders

Marinoni E, Vellucci O, Letizia C, Sessa M, Moscarini M, Di Iorio R

Il meccanismo proposto coinvolge lattivazione di recettori di fattori di crescita (VEGFR-2) e la promozione della neoformazione vascolare