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Induction of Gpx4-deficient macrophages with IL-4, which triggers M2 macrophage activation, severely disrupted the cellular redox balance and led to ferroptosis

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These findings conflicted with previous studies

doi: 10.1016/j.chom.2013.08.003 37 TsuangMTStoneWSFaraoneSV

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H 2 O 2 is the major source of oxidative stress
