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doi: 10.1016/j.placenta.2020.01.004

Newman, Rafay Khan, Shervin Shaffiy, Ali Nadhim, Anil Bhave, and Michael A

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The anti-inflammatory effects of CoQ10 are thought to protect against cardiovascular disease.[ref] Statins are the most prescribed class of drug in the U.S., and statins act to block the pathway involved in both LDL and CoQ10 production .[ref] A meta-analysis that involved data from 12 RCTs found that statins clearly reduce circulating CoQ10 levels

This was demonstrated by elevated transcript levels of autophagy-related receptors NIX and Ras Homolog Enriched in Brain (RHEB), as well as autophagy genes such as Atg9 and Atg12 , in ovarian granulosa cells of females with PCOS or in mice with PCOS induced by DHT (137, 138)