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GSH detection GSH is an essential antioxidant to maintain the redox balance of biological systems, and its abnormal levels are commonly associated with various diseases including tumors, infections, and neurodegenerative disorders 25,26,27,53,54,55,56,57

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248 Cardiac retinol metabolism disorders in patients and mice with type 2 diabetes are marked by excessive retinol and a deficiency in all-trans retinoic acid

Moreover, ER-driven autophagy has been shown to enhance cellular resistance to oxidative stress, which in the context of our study, may also contribute to protection against ferroptosis [36]

For example, PPIs are linked to nutrient deficiencies, 11 bone demineralization, 12 and higher susceptibility to infections, including Clostridium difficile