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2025 Aug 21;40(1):184

Side effects of L-Carnitine Like anything else, L-Carnitine supplementation has side effects when taken in high doses

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Nevertheless, another in vitro study in rat vascular smooth muscle cells revealed that CRP increased mRNA levels and the protein expressions of VEGF-A and inducible nitric oxide synthase, and boosted NO secretion in the medium, but it also hindered the nuclear translocation of glucocorticoid receptor and diminished its mRNA level and protein phosphorylation in these cells [142]

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The combination of sofosbuvir (200 mg or 400 mg once daily) and PEG-IFN/RBV for 12 weeks demonstrated efficacy, reaching SVR12 of 91% in HCV-1 and 92% in HCV-2/HCV-3, while it was 58% in placebo plus PEG-IFN/RBV group.[86] Recently, the LONESTAR-2 study assessed the combination of sofosbuvir plus PEG-IFN/RBV in 47 previous treatment-failure HCV-2 and HCV-3 patients (55% with compensated cirrhosis) treated for 12 weeks