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Science Bulletin

Keywords: cancer organoids, personalized therapy, extracellular matrix (ECM), decellularized matrix, ex vivo cancer models, drug screening 1 Introduction A major challenge in developing new therapies is translating scientific knowledge from the laboratory to the clinical practice (Drost and Clevers, 2018)

IL-1 is a well-established upstream regulator of age-associated inflammation and induces downstream cytokines including IL-6 and TNF 4,49

Christophe Hano, [email protected]

Chronic fatigue can seriously affect a persons quality of life and well-being

Chi-squared testwasused to compare differences between proportions, while ANOVA was used for comparison of mean differences, and Fishers exact test was used to determine the association between the healthy low risk (control), healthy high risk and oral cancer patients based on age groupings
