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The model suggests an exchange with glutamate, but no mitochondrial GABA/glutamate exchanger is known in mammalian cells, although an exchanger has been demonstrated in plants (Michaeli et al., 2011), and the cell membrane of prokaryotes (which have no mitochondria) express a glutamateGABA exchanger, GadC (Ma et al., 2012)

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When glucose is restricted, intracellular ATP levels decrease, leading to an increase in the AMP/ATP ratio

Additionally, future approaches might integrate advanced drug delivery systems, such as nanoparticles, to locally deliver HO-1 inhibitors to atherosclerotic plaques, thereby improving treatment specificity and efficacy