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Indeed, exposure of neuronal or neuron-like cells to the -amyloid results in pronounced neurite retraction and reduced cell complexity [42][45] concomitant with a significant increase in tau phosphorylation at the Ser 396 whereas other serine/threonine sites Ser199, Ser202, Thr205 and Ser404 show no significant alteration [46],[47]

Indeed, mitophagy is activated in cold-exposed BAT, as shown by electron microscopy (EM) visualization of mitochondria inside autophagosomes and the upregulation of autophagy-related proteins [230, 234]

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Serve as neurotransmitters, facilitating neural signalling between the brain and body about pain, temperature, hunger, and more

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It achieves this by inhibiting the activity of Acetyl-CoA carboxylase, an essential enzyme in the fatty acid synthesis pathway