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116,117 Additionally, Smurf1 stabilizes sterol regulatory element-binding protein-1c (SREBP-1c), a key transcription factor in lipid metabolism, by preventing its ubiquitination and degradation, while BTRC promotes the proteasomal degradation of adipose triglyceride lipase

Lysophospholipid (LPL) are produced by removing one of the tails through hydrolysis

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A key future direction involves defining optimal drug ratios and identifying predictive biomarkers to guide patient selection for such metabolically targeted combination therapies

References 1 GrayDW

LncRNA ITGB2-AS1 promotes cisplatin resistance of non-small cell lung cancer by inhibiting ferroptosis via activating the FOSL2/NAMPT axis