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Samples exposed to a single 24-hour excursion to 30C (common in summer shipping without cold packs) showed 75-80% remaining contenta 20-25% loss from one temperature spike

Toxins can lead to elevated oxidative stress and increase demand on the body's detoxification pathways, particularly in the liver

Annu Rev Cell Dev Biol 2011

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The pulsatile exposure pattern from every-other-day dosing allows partial receptor recovery between doses, slowing the rate of desensitization

Boyden ED, Dietrich WF