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Interestingly, glutaminase, the therapeutic target of Telaglenastat, was one of the targets against Palbociclib adaptation identified in this analysis

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[1] Causes of decreased production include iron deficiency, folate deficiency, vitamin B 12 deficiency, thalassemia and a number of bone marrow tumors

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This finding is particularly significant, as troponin is a sensitive marker of myocardial injury and can precede severe clinical manifestations 63