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In contrast to what was observed for murine AP180 and other human proteins containing multiple CBMs 38 , there is only one unique clathrin binding motif found per protein within yeast adaptors (Fig

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After 2 weeks of treatment, mice treated with GLP-1MK-801, as well as those subjected to calorie restriction or GLP-1 monotherapy, demonstrated enhanced glucose tolerance compared with mice that were treated with the vehicle or MK-801 monotherapy (Extended Data Fig

Notably, 8-hydroxy-2-deoxyguanosine (8-OHdG), a marker of oxidative DNA damage, is elevated in liver biopsy specimens of MASLD patients, and 31 P-MRS imaging has demonstrated ATP depletion consistent with mitochondrial dysfunction [101, 102]