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Accumulation of lipid peroxidation products, especially oxidized long-chain fatty acids, induces microglial hyperactivation and pro-inflammatory cytokine release, thereby initiating or amplifying neural damage (18)

Metabolic modulators such as metformin and pioglitazone are receiving more attention in the context of ASD, not only as supplementary therapies aimed at reducing the metabolic side effects of conventional medication, but also as potential primary interventions

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doi: 10.18502/ijph.v51i2.8683 5 Miranda-FilhoAPierosMBrayF