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Inflammation biomarkers are measurable signals that reflect inflammatory activity

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In PMS, therapeutic mechanisms of action should combine neuroprotection, immunomodulation and regeneration to hamper irreversible disability progression

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The subsequent genetic mapping and eventual cloning of at least four homologous loci in humans has since demonstrated that these genes are responsible for the etiology and pathology of the Hermansky Pudlak Syndrome of human patients (Suzuki 2001

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