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Doses are high and may sedate the cat, so they are not appropriate for daily use

Interestingly, intervention studies suggest that synbiotic combinationsprebiotic fiber plus probiotic strains such as Bifidobacterium and Lactobacillusmay help reduce circulating TMAO-producing taxa while enriching beneficial commensals (e.g., Bifidobacterium, Akkermansia) and thus decrease systemic TMAO levels [44,45,46].Hepatic FMO3 inhibition represents another target, though it carries the risk of accumulating TMA, which can cause trimethylaminuria and related toxicities [47]

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New insights in prevention and treatment of cardiovascular disease