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Anti-vascular endothelial growth factor for diabetic macular oedema

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Consistent with negative feedback by p21 on p53 levels (Broude et al, 2007), induction of p21 FL and p21 N , but not p21 C , decreased basal p53 levels and attenuated p53 stabilization upon nutlin-3 treatment, further validating the function of these proteins (Fig 2E)

This receptor pathway has over 15 years of safety data from diabetes medications, providing confidence in its long-term profile

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After the isolation and establishment of pluripotent stem cells (PSCs) from mouse embryos in 1981 (Martin, 1981) and human embryonic stem cells (ESCs) in 1998 (Thomson et al., 1998