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That depends on what you are trying to accomplish, what your labs and history look like, and what else you are taking

The average diet supplies about 5 to 15 mcg/day of vitamin B12 in a protein-bound form that is available for absorption after normal digestion

What is the best time of day to take vitamin B12 supplements

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Ageing Dev

Other issues, like atrophic gastritis (a thinning of the stomach lining), reduce the production of stomach acid, which is essential for releasing B12 from food
