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In each case, the honest framing is that the evidence is predominantly preclinical , with limited or no robust human clinical trial data on the TB-500 product itself

Unfortunately, studies on this topic have mainly focused on normalising serum B12 concentrations with oral supplementation and should be interpreted with caution since the specific goal of treatment in symptomatic B12 deficiency is alleviating symptoms, and NOT to normalize B12 concentrations in the blood

Macrophages in cardiovascular diseases: molecular mechanisms and therapeutic targets

doi: 10.1016/j.taap.2023.116609

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