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In some embodiments, a low viscosity otic formulation or device described herein provides an apparent viscosity of from about 500 cP to about 10,000 cP

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The typical human equivalent dose works out to approximately 0.0016-0.004 mg per kilogram of body weight

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Among these, cholesterol has a particularly strong effect on the electrical permeability and stability of phosphatidylcholine liposomes, suggesting that it modulates the hydrophobic barrier of the bilayer core and thereby influences membrane permeability and overall stability (Raffy and Teissi, 1999)