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However, one should bear in mind that duloxetine has previously been identified, in pre-marketing clinical trials and post-marketing monitoring, as a causative agent of liver injury (DeSanty and Amabile 2007) and thereby it had not been prescribed to patients believed to present higher susceptibility to DILI (e.g., elderly, obese patients, individuals with diabetes, chronic renal failure, etc.)

Psychiatry 84 , 223227 (2013)