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In contrast, the lifespan of mitochondrial electron transport chain deficient isp-1 mutant and raga-1 mutants, in which mTOR complex 1 activity is inhibited, remains unaffected by changes in the media (Figure 4C and D), indicating that the lifespan extension effects induced by mitochondria deficiency and TOR inhibition are resilient to environmental factors that interfere with metformin action in aging

Int J Mol Sci 19(9):2712 Ringseis R, Keller J, Eder K (2013) Mechanisms underlying the anti-wasting effect of L-carnitine supplementation under pathologic conditions: evidence from experimental and clinical studies

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Our results suggest that transient allosteric coupling between PBP1b and LpoB directs PG synthesis to areas of low peptidoglycan density, while simultaneously facilitating efficient lipoprotein redistribution to other sites in need of fortification