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The authors indicated this improvement could be resulted from intranasal delivery via olfactory and trigeminal nerve pathways
Tissues were homogenized in 510 mL of cold buffer (50 mM potassium phosphate, pH 7.5, 1 mM EDTA) per gram of tissue, followed by centrifugation at 10,000 g for 15 min at 4 C
They also observed a significant increase in the methylation levels of H3R17 in the promoter region of p21, a downstream target of CARM1 that is involved in cell cycle arrest, following RSVL treatment
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Bui BP, Nguyen PL, Lee K, Cho J
