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There is a significant increase in venous thrombosis and fatal stroke risk caused by the use of raloxifene, as well as the problem of intolerable vasomotor stability syndrome (hot flashes), which require clinicians to give comprehensive and careful consideration when using the drug (Ettinger et al., 1999

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Enolization, carbonyl migration, fission, and Strecker degradation are also reported to be absent or of limited importance

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Reaction between Cys and acetone gave incomplete formation of 36 (33%), even after addition of base (NaOD, 1 equivalent, 56% of 36 )