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It is "reduced" because it is "armed" with an extra electron that it can give away to neutralize a free radical

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These findings may, in part, explain the effects of modest (pathological) levels of homocysteine on the enhanced oxidative stress found in hyperhomocysteinemic mice (106)

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The relationships between different cell types allow for paracrine modulation which, in turn, regulates CNS homeostasis, such as BBB permeability and blood flow (Zlokovic, 2008