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Collectively, these data indicate that iron-dependent fur- regulated genes contribute to longer and more severe infections by regulating iron within the cell ( The ability to acquire specific haem sources may also be linked to the pathogenic potential of NTHi isolates

Overall, 91 patients (82.7%) met the improvement criterion, while 19 (17.3%) did not

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However, the activity reported was very low, which could be enhanced to 963-fold for a triple mutant E423Y/E442Q/D445N of BsGGT, developed by site-directed and random mutagenesis approach (Suzuki et al., 2010)