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Therefore, in patients with renal or hepatic insufficiency (or both), arginine is generally avoided or only administered with extreme caution under close monitoring

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J Clin Invest 130:17521766 Huang Y, Dai Z, Barbacioru C, Sadee W (2005) Cystine-glutamate transporter SLC7A11 in cancer chemosensitivity and chemoresistance

doi: 10.1016/S0165-0327(98)00158-X 73 DellOssoLCarmassiCMassimettiGConversanoCDaneluzzoERiccardiIet al

although this is uncommon, any history of hypersensitivity to niacinamide or NAD would be a contraindication

and by unpaired two-tailed t-test in f