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Consequently, certain pro-inflammatory cytokines and neurotransmitters can penetrate the compromised BBB and affect the central nervous system, thereby exacerbating symptoms via persistent neuroinflammation and neurotransmitter dysregulation ( Figure 1 )

Swiss Med Wkly 2004;134:385

doi: 10.7759/cureus.92349 Oduol Chelsea

On the other hand, analysis of preclinical therapeutic trials in hSOD1 G93A mouse model of ALS revealed that publication bias and poorly designed experiments such as absence of randomization and blinding, lack of adequate statistical power, and variations within the animal models may lead to over reporting of false positive results (Benatar, 2008

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